Phosphorus Radical-Initiated Cascade Reaction To Access 2-Phosphoryl-Substituted Quinoxalines

• DOI: 10.1021/acs.joc.8b01657
• Publication Date: 2018-08-30T13:37:04Z
• Authors: Yan Liu; Xiao-Lan Chen; Fan-Lin Zeng; Kai Sun; Chen Qu; Lu-Lu Fan; Zi-Long An; Rui Li; Chun-Feng Jing; Sheng-Kai Wei; Ling-Bo Qu; Bing Yu; Yuan-Qiang Sun; Yu-Fen Zhao
• Keywords: 01 natural sciences; 0104 chemical sciences

An effective radical cascade cyclization strategy was developed, by which a wide range of 2-phosphoryl-substituted quinoxalines were prepared in one pot via reaction of ortho-diisocyanoarenes with diarylphosphine oxides in the presence of AgNO3 under mild reaction conditions.