Rhodium(III)-Catalyzed C–H Activation of α-Iminonitriles or α-Imino Esters and Cyclization with Acrylates to 2H-Isoindoles

• DOI: 10.1021/acs.joc.8b01664
• Publication Date: 2018-08-29T23:47:10Z
• Authors: Yazhou Li; Jianhui Zhou; Feifei Fang; Bin Xu; Hong Liu; Yu Zhou
• Keywords: Isoindole

Rh(III) catalysts have played increasingly important roles in the activation of C–H bonds to build heterocyclic scaffolds. However, there are few reports on more challenging synthesis pharmaceutically 2H-isoindoles and fused 2H-isoindoles. The process reported herein is an effective strategy produce 2H-isoindole or derivatives via a Rh(III)-catalyzed transformation α-iminonitriles α-imino esters with acrylates.