Metal-Free Regioselective Cross Dehydrogenative Coupling of Cyclic Ethers and Aryl Carbonyls

• DOI: 10.1021/acs.joc.8b03048
• Publication Date: 2019-01-15T18:12:18Z
• Authors: Kishor D. Mane; Anagh Mukherjee; Kumar Vanka; Gurunath Suryavanshi
• Keywords: 01 natural sciences; 0104 chemical sciences

A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC) of aryl carbonyls with cyclic ethers has been developed. This method offers easy access to substituted α-arylated cyclic ethers with a high functional group tolerance in good to excellent yields. The regioselectivity of this CDC reaction was confirmed by density functional theory (DFT)-based calculations.