Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

• DOI: 10.1021/acs.joc.9b00324
• Publication Date: 2019-02-21T14:44:26Z
• Authors: Devin M. Ferguson; Christian A. Malapit; James R. Bour; Melanie S. Sanford
• Keywords: 01 natural sciences; 0104 chemical sciences

A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(PtBu3)2, are demonstrated provide a variety difluoromethylated arenes in good yields.