Metal-Free Trifluoroalkylation of Quinoxalin-2(1H)-ones with Unactivated Alkenes and Langlois’ Reagent

• DOI: 10.1021/acs.joc.9b03505
• Publication Date: 2020-05-11T21:12:49Z
• Authors: Na Meng; Leilei Wang; Qishun Liu; Qinyu Li; Yufen Lv; Huilan Yue; Xiaojuan Wang; Wei Wei
• Keywords: 01 natural sciences; 0104 chemical sciences

A K2S2O8-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1H)-ones under metal-free conditions. The present reaction could be accomplished through trifluoroalkylation with unactivated alkenes and Langlois' reagent (CF3SO2Na), which provided a highly attractive approach to access series biologically important quinoxalin-2(1H)-ones.