Multiphysics Modeling of Plasmonic Photothermal Heating Effects in Gold Nanoparticles and Nanoparticle Arrays

• DOI: 10.1021/acs.jpcc.0c02443
• Publication Date: 2020-07-06T19:19:47Z
• Authors: Santiago Manrique...; Mohammad Abdul-Mo...; Priscilla Lopez; Tara Gray; Matthew Disiena; Andrew Locker; Sharon Kwee; Liang Tang; R. Lyle Hood; Yusheng Feng; Nicolas Large; Kathryn M. Mayer
• Keywords: Nanorod; Plasmonic Nanoparticles; Multiphysics; Heat Generation; Photothermal effect

Induced hyperthermia has been demonstrated as an effective oncological treatment due to the reduced heat tolerance of most malignant tissues; however, techniques for generation within a target volume are insufficiently selective, inducing heating and unintended damage surrounding healthy tissues. Plasmonic photothermal therapy (PPTT) utilizes light in near-infrared (NIR) region induce highly localized gold nanoparticles, acting exogenous chromophores, while minimizing nearby However, optimization parameters requires extensive vitro vivo studies each new type pathology tissue targeted treatment, process that can be substantially by implementing computational modeling. Herein, we describe development innovative model based on finite element method (FEM) unites physics at nanoscale with micron scale predict both single arrays nanoparticles. from laser illumination is computed nanoparticles three different morphologies: nanobipyramids, nanorods, nanospheres. Model predictions nanorods visible wavelength (655 nm) validated through experiments, which demonstrate temperature increase 5 °C viscinity nanorod array when illuminated 150 mW red laser. We also present predictive effect induced 810 nm, wherein efficiencies various morphologies sharing this excitation peak compared. Our shows isolated scenario, 91 nm long reached hyperthermic levels (an least °C) over 20 μm3.