Gut Microbiota-Derived Metabolite Signature in Suckling and Weaned Piglets

• DOI: 10.1021/acs.jproteome.0c00745
• Publication Date: 2020-12-09T18:28:20Z
• Authors: Martin Beaumont; Laurent Cauquil; Allan Bertide; Ingrid Ahn; Céline Barilly; Lisa Gil; Cécile Canlet; Olivier Zemb; Géraldine Pascal; Arnaud Samson; Sylvie Combes
• Keywords: Metabolome; Ruminococcus

The gut microbiota plays a key role in intestinal development at the suckling-to-weaning transition. objective of this study was to analyze production metabolites by suckling and weaned piglets. We studied piglets raised two separate maternity farms postnatal day 21 same farm. fecal metabolome (1H nuclear magnetic resonance) composition (16S rRNA gene amplicon sequencing) its predicted functions (PICRUSt2) were analyzed during period (postnatal 13) 2 days after weaning 23). relative concentrations bacterial methylamine, dimethylamine, cadaverine, tyramine, putrescine, 5-aminovalerate, succinate, 3-(4-hydroxyphenylpropionate) higher than weaning. In contrast, short-chain fatty acids acetate propionate period. origin also influenced level some (propionate isobutyrate). signatures observed associated with specific microbiota-predicted functionalities, structure, diversity. Gut microbiota-derived metabolites, which are differentially abundant between (e.g., biogenic amines), known regulate health. Thus, identification paves way for health-promoting nutritional strategies, targeting early life.