Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies

• DOI: 10.1021/acs.jproteome.6b00980
• Publication Date: 2017-04-05T17:13:28Z
• Authors: Álvaro Sierra-Sán...; Diego Garrido-Martín; Lucía Lourido; María González-Go...; Paula Díez; Cristina Ruiz-Romero; Ronald Sjöber; Conrad Droste; Javier De Las Rivas; Peter Nilsson; Francisco Blanco; Manuel Fuentes
• Keywords: Biomarker Discovery

Osteoarthritis (OA) is one of the most prevalent articular diseases. The identification proteins closely associated with diagnosis, progression, prognosis, and treatment response dramatically required for this pathology. In work, differential serum protein profiles have been identified in OA rheumatoid arthritis (RA) by antibody arrays containing 151 antibodies against 121 antigens a cohort 36 samples. Then validated larger 282 overall immunoreactivity higher pathological situations comparison controls. Several as biomarker candidates RA. Most these are related to inflammatory response, lipid metabolism, or bone extracellular matrix formation, degradation, remodeling.