Reduced Graphene Oxide Nanosheet for Chemo-photothermal Therapy

• DOI: 10.1021/acs.langmuir.6b00315
• Publication Date: 2016-03-02T00:10:56Z
• Authors: Yeong Ah Cheon; Jun Hyuk Bae; Bong Geun Chung
• Keywords: Nanosheet

The protein-functionalized reduced graphene oxide (rGO) nanosheet is of great interest in stimuli-responsive drug delivery and controlled release applications. We developed doxorubicin (DOX)-loaded bovine serum albumin (BSA)-functionalized rGO (DOX-BSA-rGO) nanosheets. To investigate the reduction BSA-functionalized GO nanosheets loading efficiency, we used X-ray photoelectron spectroscopy (XPS) UV–visible spectrophotometer analysis. DOX-BSA-rGO exhibited dose-dependent cellular uptake without any cytotoxic effect. also demonstrated near-infrared (NIR)-induced chemo-photothermal therapy brain tumor cells treated with Therefore, this could be a powerful tool for