Polyanionic Antimicrobial Membranes: An Experimental and Theoretical Study

• DOI: 10.1021/acs.langmuir.7b00185
• Publication Date: 2017-04-08T03:07:52Z
• Authors: Jiangna Guo; Qiming Xu; Rongwei Shi; Zhiqiang Zheng; Hailei Mao; Feng Yan
• Keywords: 02 engineering and technology; 0210 nano-technology; 3. Good health

Polycationic polymers have been widely used as antimicrobial materials because of their broad spectrum activity and potential use new antibiotics. Herein, we report the synthesis polyanionic membranes by in situ photo-cross-linking a sulfate based anionic monomer, followed cation-exchange with organic (quaternary ammonium or imidazolium) metal (Ag+, Cu2+, Fe3+, Zn2+, Na+, K+) cations. The resultant show high antibacterial activities against both bacteria (Escherichia coli, Staphylococcus aureus) fungi (Candida albicans ). In addition, efficiently inhibited formation biofilms SC5314 its crk1 gene deleted (Δcrk1) C. strains. Furthermore, synthesized exhibit good blood compatibility, low cytotoxicity long-term stability, demonstrating safe application healthcare.