The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

• DOI: 10.1021/acs.langmuir.7b02568
• Publication Date: 2017-10-12T14:18:53Z
• Authors: Priya S. R. Naidu; Marck Norret; Nicole M. Smith; Sarah A. Dunlop; Nicolas L. Taylor; Melinda Fitzgerald; K. Swaminathan Iyer
• Keywords: Biomolecule; Corona (planetary geology); PEGylation; Glycidyl methacrylate; Surface Modification

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to non-PEGylated PGMA NPs. Despite reputation PEGylated NPs for stealth functionality, we demonstrate preferential enrichment specific serum proteins varied biological function in when Additionally, suggest that base material polymeric plays a role select hard corona.