Effective Delivery of Paclitaxel-Loaded Ferritin via Inverso CendR Peptide for Enhanced Cancer Therapy

• DOI: 10.1021/acs.molpharmaceut.2c00616
• Publication Date: 2022-12-27T17:37:54Z
• Authors: Yixin Dong; Kun Yang; Zicheng Xu; Xun Li; Fei Wang; Yu Zhang
• Keywords: Nanocarriers

The application of drug delivery systems based on ferritin nanocarrier has been developed as a potential strategy in cancer therapy. limited permeability remains challenge for penetration into the deeper tumor tissues. CendR peptides have reported to bear tumor-specific by recognizing neuropilin (NRP-1) receptor that overexpressed wide range cells. Herein, we modified peptide L(RGERPPR), its retro-inverso D(RPPREGR), and inverso D(RGERPPR) outer surface human H chain sulfhydryl-maleimide coupling reaction. Approximately 45 paclitaxel (PTX) molecules could be loaded each inner cavity thermal-triggered method at specific ionic strength. ability three peptide-modified constructs showed D(RGERPPR)-modified HFtn was able engulfed A549 MCF-7 cells spheroids highest level. Due dual-targeting effect peptides, PTX-loaded nanocomposites effectively enter with high expression TfR1 NRP-1 receptors enhanced cytotoxicity against Remarkably, H-D(RGE)-PTX displayed superior growth suppression efficacy tumor-bearing nude mice. first generated provide an effective platform treatment cancers.