The Effect of Lipid Composition on the Liposomal Delivery of Camptothecin Developed by Active Click Loading

• DOI: 10.1021/acs.molpharmaceut.3c01140
• Publication Date: 2024-04-05T07:31:40Z
• Authors: Lei Xie; Qian Zhang; Qian Zhu; Yang Wang; Shuijiao Niu; Xinyue Zhang; Yuting Huang; Jiayao Li; Xiaoxue Liu; Zhiyuan Xue; Xia Zhao; Yaxin Zheng
• Keywords: Camptothecin

In the present study, we investigated role of lipid composition camptothecin (CPT)-loaded liposomes (CPT-Lips) to adjust their residence time, drug distribution, and therefore toxicities antitumor activity. The CPT was loaded into using a click loading method, which utilized preloaded with GSH then exposed CPT-maleimide. method produced CPT-Lips high encapsulation efficiency (>95%) sustained release. It is shown that times in body were highly dependent on compositions an order non-PEGylated unsaturated lipids < saturated PEGylated lipids. Interestingly, fast clearance resulted significantly decreased but did not cause significant decrease vivo These results suggested could effectively time further optimize therapeutic index, would guide development liposomal formulation CPT.