Polymer-Based Nanoparticles with Probucol and Lithocholic Acid: A Novel Therapeutic Approach for Oxidative Stress-Induced Retinopathies

• DOI: 10.1021/acs.molpharmaceut.4c00269
• Publication Date: 2024-06-20T10:11:01Z
• Authors: Susbin Raj Wagle; Bozica Kovacevic; Corina Mihaela Io...; Thomas Foster; Patrick Lim; Alicia Brunet; Samuel McLenachan; Livia Carvalho; Momir Mikov; Armin Mooranian; Hani Al-Salami
• Keywords: Probucol

Oxidative stress is pivotal in retinal disease progression, causing dysfunction various components. An effective antioxidant, such as probucol (PB), vital to counteract oxidative and emerges a potential candidate for treating degeneration. However, the challenges associated with delivering lipophilic drugs PB posterior segment of eye, specifically targeting photoreceptor cells, necessitate innovative solutions. This study uses formulation-based spray dry encapsulation technology develop polymer-based PB-lithocholic acid (LCA) nanoparticles assesses their efficacy 661W photoreceptor-like cell line. Incorporating LCA enhances nanoparticles' biological without compromising stability.