Development and Preclinical Evaluation of 18F-Labeled PEGylated Sansalvamide A Decapeptide for Noninvasive Evaluation of Hsp90 Status in Pancreas Cancer

• DOI: 10.1021/acs.molpharmaceut.4c00643
• Publication Date: 2024-09-24T15:17:32Z
• Authors: Xiaohui Wang; Zhijian Han; Jun Zhang; Ming Chen; Wenbo Meng

Heat shock protein 90 (Hsp90) is a promising target for cancer therapy and imaging. Accurate detection of Hsp90 levels in tumors via noninvasive PET imaging might be beneficial management. To achieve this, the precursor compound Dimer-Sansalvamide A (Dimer-San A) was PEGylated modified by conjugating it with bifunctional chelator 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA). The