Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles
Male
Mice, Inbred BALB C
0303 health sciences
Paclitaxel
Polyesters
Mice, Nude
Glioma
Antineoplastic Agents, Phytogenic
Polyethylene Glycols
Rats
3. Good health
Mice
03 medical and health sciences
Drug Delivery Systems
Cell Line, Tumor
Human Umbilical Vein Endothelial Cells
Animals
Humans
Nanoparticles
Glioblastoma
DOI:
10.1021/acs.molpharmaceut.6b00523
Publication Date:
2016-09-16T19:18:32Z
AUTHORS (11)
ABSTRACT
Combining treatment of anticancer cells and antiangiogenesis is considered to be a potential targeted strategy for brain glioblastoma therapy. In this study, by utilizing the overexpression Interleukin 13 receptor α2 (IL-13Rα2) on glioma heparan sulfate neovascular endothelial cells, we developed paclitaxel (PTX) loaded Pep-1 CGKRK peptide-modified PEG–PLGA nanoparticle (PC-NP-PTX) neovasculature dual-targeted chemotherapy enhance antiglioma efficacy. There were significant differences both enhancement cellular uptake in HUVEC C6 improvement vitro activity respect proliferation, tumor spheroid growth, tube formation, migration between PC-NP-PTX Taxol NP-PTX. As IC50 3.59 ± 0.056, 2.37 0.044, 1.38 0.028, 1.82 0.035, 1.00 0.016 μg/mL Taxol, NP-PTX, Pep-NP-PTX, CGKRK-NP-PTX, PC-NP-PTX, 0.44 0.006, 0.33 0.005, 0.25 0.19 0.004, 0.16 0.004 respectively. vivo distribution assays confirmed that accumulated effectively at site. showed longer median survival time 61 days when compared with (22 days), NP-PTX (24 Pep-NP-PTX (32 CGKRK-NP-PTX (34 days). The efficacy safety evaluation significantly enhanced displayed negligible acute toxicity.
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