Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates

• DOI: 10.1021/acs.molpharmaceut.8b00488
• Publication Date: 2018-07-09T20:29:10Z
• Authors: Tahnee J. Dening; Lynne S. Taylor
• Keywords: Supersaturation

Ordered mesoporous silica materials have shown great potential as oral drug delivery systems for poorly soluble drugs. However, the ability of these to generate supersaturation has not been widely investigated, and recently noted phenomenon incomplete release is well understood. Therefore, aim this study was comprehensively evaluate hydrophobic molecules into solution from ordered silica, focusing on extent duration supersaturation. The dissolution behavior ritonavir, following loading SBA-15 particles, investigated by undertaking simple in vitro studies phosphate buffer pH 6.8 fasted state simulated intestinal fluid, membrane flux using a side-by-side diffusion cell apparatus. It found that supersaturated ritonavir solutions were generated ritonavir-loaded particles; however, always incomplete, even under sink conditions. In addition, percentage observed decrease significantly theoretical ratio dose formulation increased. data obtained suggest an equilibrium exists between adsorbed surface free present solution. findings described herein are highly significant aiding our understanding supersaturating system bioavailability enhancement.