Inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis

• DOI: 10.1021/acs.molpharmaceut.8b01342
• Publication Date: 2019-02-12T22:43:47Z
• Authors: Xu Zhou; Xi Cao; He Tu; Zhi-Rong Zhang; Li Deng
• Keywords: Celastrol

Celastrol (CLT)-loaded PEG–PLGA nanoparticles (NPs/CLT) coated with neutrophil membranes (NNPs/CLT) were explored for the management of acute pancreatitis (AP). sized around 150 nm proven to selectively accumulate in pancreas rats AP. NNPs found overcome blood–pancreas barrier and specifically distributed pancreatic tissues. Moreover, showed more selective accumulation than without any membrane coating AP rats. Compared CLT solution NPs/CLT group, NNPs/CLT significantly downregulated levels serum amylase myeloperoxidase Also, using as delivery vehicle reduced systemic toxicity Together, these results suggest that represent a highly promising targeted therapy