Dual-Arm Nanocapsule Targets Neuropilin-1 Receptor and Microtubule: A Potential Nanomedicine Platform

• DOI: 10.1021/acs.molpharmaceut.9b00123
• Publication Date: 2019-04-22T17:24:18Z
• Authors: Surajit Barman; Gaurav Das; Varsha Gupta; Prasenjit Mondal; Batakrishna Jana; Debmalya Bhunia; Juhee Khan; Deepshikha Mukherjee; Surajit Ghosh
• Keywords: Nanocapsules

A multiarm nanomedicine template has been designed following bottom-up approach, which target neuropilin-1 (Nrp-1) receptor of cancer cells. Through this venture, we discovered that cucurbit [6] uril (CB [6]) binds with tubulin close to binding pocket vinblastine site and perturbs polymerization. To increase the specificity gold nanoparticle (GNP) toward Nrp-1-rich cells, further modified GNP Nrp-1 receptor-specific short peptide (CGNKRTR). Remarkably, found an interesting self-assembly process upon addition curcumin into CB peptide-functionalized GNP, leading formation a spherical nanocapsule (CGNP·Cur). It can deliver release significantly higher amounts anticancer drug in causes microtubule depolymerization significant tumor regression overexpressed mice melanoma model. These findings show high potential develop powerful help its preclinical validation.