Effect of Surface Charges on Oral Absorption of Intact Solid Lipid Nanoparticles

• DOI: 10.1021/acs.molpharmaceut.9b00861
• Publication Date: 2019-10-23T16:03:13Z
• Authors: Zhou Yu; Wufa Fan; Luting Wang; Jianping Qi; Yi Lu; Wei Wu
• Keywords: Nanocarriers; Solid lipid nanoparticle; Surface charge; Cationic polymerization; Penetration (warfare)

Surface charge is a crucial factor that determines the in vivo behaviors of drug nanocarriers following administration via different routes. However, there still lack comprehensive knowledge how surface charges affect particles, especially for oral delivery. In this study, solid lipid nanoparticles (SLNs), as model nanocarriers, are modified to bear either anionic, cationic, or net neutral charges. The effect on absorption intact SLNs was investigated by tracking transport particles. fluorescent bioimaging strategy exploits aggregation-caused quenching property discriminate Both vitro and lipolysis studies confirm slowed-down anionic comparison with both unmodified but accelerated degradation cationic scanning ex tissues organs reveals limited into circulation. Nevertheless, all three types modifications able enhance fastest highest observed SLNs, possibly owing promoted mucus penetration. Anionic though repulsed layer, show second enhanced lymphatic transport. efficacy modification less significant due entrapment retention layers well increased lability lipolysis. conclusion, may serve initiators guide SLNs.