Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces

• DOI: 10.1021/acs.nanolett.0c00974
• Publication Date: 2020-03-25T20:10:16Z
• Authors: Youjin V. Lee; David Wu; Yun Fang; Yuxing Peng; Bozhi Tian
• Keywords: Nanomaterials

The rolling motion (i.e., longitudinal rotation) of nanomaterials may serve as a proxy to probe microscopic environments. Furthermore, nanoscale rotations in biological systems are common but difficult measure. Here, we report new tool that measures nanowire with short arm grown at one end. We present particle detection algorithm subpixel resolution and image segmentation principal component analysis enables precise automated determination the orientation. show nanowires' dynamics can be significantly affected by their surroundings demonstrate probes' ability reflect different nanobio interactions. A non-cell-interacting undergoes rapid subdiffusive rotation, while cell-interacting exhibits superdiffusive unidirectional rotation when cell membrane actively interacts slow it is fully encompassed cell. Our method used yield insights into various biophysical assembly processes.