Graphene Electric Field Sensor Enables Single Shot Label-Free Imaging of Bioelectric Potentials

• DOI: 10.1021/acs.nanolett.1c00543
• Publication Date: 2021-06-08T21:47:07Z
• Authors: Halleh B. Balch; Allister F. McGuire; Jason Horng; Hsin-Zon Tsai; Kevin K. Qi; Yi-Shiou Duh; Patrick R. Forrester; Michael F. Crommie; Bianxiao Cui; Feng Wang
• Keywords: Temporal resolution; Local field potential

The measurement of electrical activity across systems excitable cells underlies current progress in neuroscience, cardiac pharmacology, and neurotechnology. However, bioelectricity spans orders magnitude intensity, space, time, posing substantial technological challenges. development methods permitting network-scale recordings with high spatial resolution remains key to studies electrogenic cells, emergent networks, bioelectric computation. Here, we demonstrate single-shot label-free imaging extracellular potentials a wide field-of-view. critically coupled waveguide-amplified graphene electric field (CAGE) sensor leverages the field-sensitive optical transitions convert into regime. As proof-of-concept, use CAGE detect native from action tens-of-microns resolution, simultaneously map propagation these at tissue-scale, monitor their modification by pharmacological agents. This platform is robust, scalable, compatible existing microscopy techniques for multimodal correlative imaging.