Real-Time Imaging of Hepatic Inflammation Using Hydrogen Sulfide-Activatable Second Near-Infrared Luminescent Nanoprobes

• DOI: 10.1021/acs.nanolett.1c00548
• Publication Date: 2021-05-20T20:08:20Z
• Authors: Qin Liu; Yang Zhong; Yaoquan Su; Lingzhi Zhao; Juanjuan Peng
• Keywords: Absorbance; Lead sulfide; Persistent luminescence

The sensing and visualized monitoring of hydrogen sulfide (H2S) in vivo is crucial to understand its physiological pathological roles human health diseases. Common methods for H2S detection require the destruction biosamples are not suitable be applied vivo. In this Communication, we report a "turn-on" second near-infrared (NIR-II) luminescent approach sensitive, real-time, situ detection, which based on absorption competition between H2S-responsive chromophores (compound 1) NIR-II lanthanide nanoparticles. Specifically, luminescence was suppressed by compound 1 due competitive incident light. presence H2S, bleached recover luminescence. Thanks deep tissue penetration depth low absorbance/scattering biological samples nanoprobes, endogenous lipopolysaccharide-induced liver inflammation achieved, unattainable conventional histopathological serological approaches.