Low Colorectal Tumor Removal by E-Cadherin Destruction-Enabled Tumor Cell Dissociation

0301 basic medicine 0303 health sciences 03 medical and health sciences Cell Line, Tumor Tumor Microenvironment Humans Cadherins Colorectal Neoplasms Edetic Acid 3. Good health
DOI: 10.1021/acs.nanolett.1c04797 Publication Date: 2022-03-25T23:47:25Z
ABSTRACT
Treatments for low colorectal cancer (CRC) remain a great challenge due to the heavy physical and psychological burdens of colostomy, strong drug toxicity in chemotherapy, myelosuppression-/chemoradiation-related gastrointestinal symptoms. In this study, highly biosafe effective tumor cell dissociation-based CRC treatment modality has been verified on both PDOs vitro models vivo. Notably, controllable EDTA release at sites was achieved by LDH degradation response slightly acidic microenvironment tumors. Resultantly, intratumoral E-cadherin intercellular junctions tumors effectively destroyed via Ca2+ depletion released from interlayers, initiating remarkable dissociation resultant disaggregation/removal defecation. Dissociated cells were prevailingly enveloped LDH/EDTA, which prevented them readhering adjacent tissues, providing an unprecedented, efficient safe therapeutic CRC, will benefit patients suffering CRC.
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