Low Colorectal Tumor Removal by E-Cadherin Destruction-Enabled Tumor Cell Dissociation

• DOI: 10.1021/acs.nanolett.1c04797
• Publication Date: 2022-03-25T23:47:25Z
• Authors: Man Li; Qunqun Bao; Jing Guo; Ruting Xie; Chao Shen; Qing Wei; Ping Hu; Huanlong Qin; Jianlin Shi
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Cell Line, Tumor; Tumor Microenvironment; Humans; Cadherins; Colorectal Neoplasms; Edetic Acid; 3. Good health

Treatments for low colorectal cancer (CRC) remain a great challenge due to the heavy physical and psychological burdens of colostomy, strong drug toxicity in chemotherapy, myelosuppression-/chemoradiation-related gastrointestinal symptoms. In this study, highly biosafe effective tumor cell dissociation-based CRC treatment modality has been verified on both PDOs vitro models vivo. Notably, controllable EDTA release at sites was achieved by LDH degradation response slightly acidic microenvironment tumors. Resultantly, intratumoral E-cadherin intercellular junctions tumors effectively destroyed via Ca2+ depletion released from interlayers, initiating remarkable dissociation resultant disaggregation/removal defecation. Dissociated cells were prevailingly enveloped LDH/EDTA, which prevented them readhering adjacent tissues, providing an unprecedented, efficient safe therapeutic CRC, will benefit patients suffering CRC.