Cellulose-Based Cryogel Microspheres with Nanoporous and Controllable Wrinkled Morphologies for Rapid Hemostasis

• DOI: 10.1021/acs.nanolett.2c02144
• Publication Date: 2022-08-01T04:53:25Z
• Authors: Zhan Xu; Weiguo Tian; Chaojun Wen; Xin Ji; Huailing Diao; Yuzhen Hou; Jialiang Fan; Zongxi Liu; Tianjiao Ji; Feifei Sun; Decheng Wu; Jun Zhang
• Keywords: Nanoporous

First-aid hemostatic agents for acute bleeding can save lives in emergency situations. However, rapid hemostasis remains challenging when uncontrolled hemorrhage occurs on lethal noncompressible and irregular wounds. Herein, cellulose-based cryogel microspheres with deliberately customized micromorphologies ultrafast water transportation diffusion, including the shark skin riblet-inspired wrinkled surface low fluid drag hydrophilic nanoporous 3D networks, are developed to deal within seconds. These rapidly absorb a large amount of blood over 6 times their own weight 10 s form robust barrier seal wound without applying pressure. Remarkably, massive from cardiac penetrating hole is effectively stopped using 20 no leakage observed after 30 min. Additionally, these could be readily removed rebleeding capillary thrombus, which highly favorable rescue.