Robust Oxidase-Mimetic Supramolecular Nanocatalyst for Lignin Biodegradation

• DOI: 10.1021/acs.nanolett.3c04505
• Publication Date: 2024-02-15T20:46:03Z
• Authors: Yuanxi Liu; Yan Li; Haifeng Wu; Shichao Xu; Baoli Zhang; Shan Li; Ruikai Du; Minquan Jiang; Ziman Chen; Yongqin Lv; Zhen-Gang Wang
• Keywords: Ionic Liquids; Amino Acids; Oxidoreductases; Lignin; Copper; Catalysis

Enzymatic catalysis presents an eco-friendly, energy-efficient method for lignin degradation. However, challenges arise due to the inherent incompatibility between enzymes and native lignin. In this work, we introduce a supramolecular catalyst composed of fluorenyl-modified amino acids Cu2+, designed based on aromatic stacking fluorenyl group, which can operate in ionic liquid environments suitable dissolution Amino halide anions liquids shape copper site's coordination sphere, showcasing remarkable catechol oxidase-mimetic activity. The exhibits thermophilic property, maintains oxidative activity up 75 °C, allows catalyzed degradation as-dissolved with high efficiency even without assistance electron mediator. contrast, at condition, copper-dependent oxidase completely lost its This superior stability offer promise sustainable valorization through biocatalytic routes compatible pretreatment, addressing limitations industrially relevant conditions.