A Rapidly Synthesized, Ultrasmall Silver Nanocluster for Near-Infrared-II Imaging and Metabolic Studies

• DOI: 10.1021/acs.nanolett.4c05525
• Publication Date: 2025-01-06T08:57:52Z
• Authors: Yao Huang; Jialian Li; Hui Feng; Huan Du; Zhiming Deng

Near-infrared-II (NIR-II) imaging has emerged as a powerful technique for high-resolution visualization of deep anatomical features, benefiting from minimized autofluorescence, diminished optical scattering, and absorption tissue. However, the current synthesis NIR-II nanoprobes is time-consuming, labor-intensive process with low yields, highlighting need an efficient rapid approach instead. Herein, we report DNA-templated silver nanoclusters (Ag NCs) emission that can be rapidly synthesized via simple one-spot within 2 min. The Ag NCs are about 1.6 nm in size, making it easy them to enter into capillaries muscle In vivo results indicate designed promising probes studying metabolic pathways after intramuscular injection. Therefore, expected ultrafast room temperature synthesis, excellent emission, ultrasmall size will ideal biological applications.