Magnetically Coated Bioabsorbable Stents for Renormalization of Arterial Vessel Walls after Stent Implantation

• DOI: 10.1021/acs.nanolett.7b04096
• Publication Date: 2017-12-22T06:27:45Z
• Authors: J.S. Lee; P. Han; E. Song; D. Kim; H. Lee; M. Labowsky; J. Taavitsainen; S. Ylä-Herttuala; J. Hytönen; M. Gülcher; K. Perampaladas; A.J. Sinusas; J. Martin; A. Mathur; T.M. Fahmy
• Keywords: Arterial wall

The insertion of a stent in diseased arteries is common endovascular procedure that can be compromised by the development short- and long-term inflammatory responses leading to restenosis thrombosis, respectively. While treatment with drugs, either systemic or localized, has decreased incidence thrombosis these complications persist are associated high mortality those present thrombosis. We reasoned if stents could made undergo accelerated endothelialization deployed region, then such an approach would further decrease occurrence thereby improving clinical outcomes. Toward objective, first step necessitated efficient capture progenitor stem cells, which eventually become new endothelium. To achieve this we engineered intrinsic ferromagnetism within nonmagnetizable, biodegradable magnesium (Mg) bare metal stents. Mg were coated polylactide (PLA) polymer embedding magnetizable iron-platinum (FePt) alloy nanoparticles, nanomagnetic particles, nMags, increased surface area hence magnetization stent. nMags uniformly distributed on enabled capture, under flow, up 50 mL/min, systemically injected iron-oxide-labeled (IO-labeled) cells. Critical parameters enhancing efficiency optimized, demonstrated generality showing nMag-coated different cell types. Our work potential paradigm shift engineering because implants rendered as tissue body, "natural stealthiness" reduces eliminates issues pro-inflammatory immune postimplantation.