Double Switch Biodegradable Porous Hollow Trinickel Monophosphide Nanospheres for Multimodal Imaging Guided Photothermal Therapy

• DOI: 10.1021/acs.nanolett.9b01370
• Publication Date: 2019-06-27T08:51:38Z
• Authors: Yang Liu; Wenyao Zhen; Yinghui Wang; Jianhua Liu; Longhai Jin; Tianqi Zhang; Songtao Zhang; Ying Zhao; Na Yin; Rui Niu; Shuyan Song; Lei Zhang; Hongjie Zhang
• Keywords: NIP; Bovine serum albumin; Nanomaterials

Due to the limitation of inorganic nanomaterials in present clinical applications induced by their inherent nonbiodegradability and latent long-term side effects, we successfully prepared double switch degradable clearable trinickel monophosphide porous hollow nanospheres (NiP PHNPs) modified with bovine serum albumin (BSA). Attributed acidic oxidative degradation capacities, NiP PHNPs can be effectively excreted from mice without toxicity. Moreover, because paramagnetic high molar extinction coefficient property resulting strong absorption second near-infrared light (NIR II) biowindow, have potential used for photoacoustic imaging (PAI) T1-weighted magnetic resonance (MRI) guided photothermal ablation tumors NIR II biowindow. Specifically, it is interesting that structure enable act as intelligent drug carriers an on-demand release ability. These findings highlight great cancer theranostics field inspire us further broaden bioapplications transition metal phosphides.