Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core
01 natural sciences
0104 chemical sciences
12. Responsible consumption
DOI:
10.1021/acs.oprd.0c00246
Publication Date:
2020-10-20T11:44:10Z
AUTHORS (19)
ABSTRACT
The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic u...
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