Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core

01 natural sciences 0104 chemical sciences 12. Responsible consumption
DOI: 10.1021/acs.oprd.0c00246 Publication Date: 2020-10-20T11:44:10Z
ABSTRACT
The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic u...
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