Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M

• DOI: 10.1021/acs.oprd.0c00303
• Publication Date: 2020-08-03T15:42:40Z
• Authors: Min Shi; Ning Ye; Wei Chen; Hui Wang; Chiming Cheung; Michael Parmentier; Fabrice Gallou; Bin Wu
• Keywords: Amide

The technology of surfactant chemistry is employed for amide bond construction via the reaction acyl chlorides with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling