Nitrosamine Reactivity: A Survey of Reactions and Purge Processes

• DOI: 10.1021/acs.oprd.1c00162
• Publication Date: 2021-07-18T18:48:26Z
• Authors: Christopher J. Bo...; Michael Burns; Timothy Curran; Nathan D. Ide
• Keywords: Nitrosamine; Reactivity; Scrutiny

Drug recalls have led to increased regulatory scrutiny into the formation and presence of nitrosamine (N-nitrosoamine) impurities in medicines. This review aims assist development risk mitigation strategies by summarizing known reactions nitrosamines, with a focus on useful within context complex molecule synthesis. should serve as reference help lead chemical processes which effectively control nitrosamines.