Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran

• DOI: 10.1021/acs.oprd.1c00246
• Publication Date: 2021-11-04T08:12:36Z
• Authors: Rachel Bijoy; Pratibha Agarwala; Lisa Roy; Bhaskar N. Thorat
• Keywords: Environmentally Friendly; Organic Synthesis; Biocatalysis

Solvents are crucial platforms in organic synthesis. Thereby, the choice of a solvent is critical order to develop sustainable eco-friendly synthetic methodologies. Hence, present consensus employ environmentally friendly solvents which have broad applications fine chemical syntheses, especially from context large-scale industrial preparations. In this review, we provide several examples for utilization 2-MeTHF, CPME, and 4-MeTHP reactions pertaining organometallic-, organo-, biocatalysis highlight their potential use as benign alternatives conventional ether solvents. These favorable physical characteristics, such low toxicity high thermal stabilities, make them promising media large breadth chemistry triggers development with green protocols.