Synthesis and Applications of Periodate for Fine Chemicals and Important Pharmaceuticals

• DOI: 10.1021/acs.oprd.2c00161
• Publication Date: 2022-09-01T15:22:11Z
• Authors: Sebastian Arndt; Philipp J. Kohlpa...; Kai Donsbach; Siegfried R. Wald...
• Keywords: 540 Chemistry and allied sciences; ddc:540; 540 Chemie; 540; 01 natural sciences; 620; 0104 chemical sciences

An emerging interest for the application of periodate in the synthesis of active pharmaceutical ingredients (APIs) and for the valorization of renewable feedstock is eminent. However, periodate exhibits a high molecular mass, is expensive compared to other common bulk-oxidizers and is used only reluctantly in technical applications. Recently, a new and green electrochemical synthesis was established. The preparation and regeneration method for periodate lowers costs and enables the use of periodate in the synthesis of regulated products. This review will briefly introduce the key innovations in the electrochemical synthesis of periodate and will survey the most important applications of periodate in the production of fine chemicals.