T3P-Mediated N–N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5-a]pyridines

• DOI: 10.1021/acs.oprd.9b00396
• Publication Date: 2019-10-28T18:32:03Z
• Authors: Rajaram Ayothiraman; Durgarao Bandaru; Ranjitha Paranthaman; Michaël Fenster; Martin D. Eastgate; Rajappa Vaidyanathan
• Keywords: Functional group; Reaction conditions

Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]triazolo[1,5-a]pyridines from corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering triazolopyridines in good excellent yields purities.