Selective Cross-Dehydrogenative C(sp3)–H Arylation with Arenes

• DOI: 10.1021/acs.orglett.0c00588
• Publication Date: 2020-03-03T12:23:23Z
• Authors: Hong-Yan Hao; Yang-Jie Mao; Zhen-Yuan Xu; Shao-Jie Lou; Dan-Qian Xu
• Keywords: 01 natural sciences; 0104 chemical sciences

Selective C(sp3)–C(sp2) bond construction is of central interest in chemical synthesis. Despite the success classic cross-coupling reactions, cross-dehydrogenative coupling between inert C(sp3)–H and C(sp2)–H bonds represents an attractive alternative toward new bonds. Herein, we establish a selective inter- intramolecular arylation alcohols with nondirected arenes that thereby provides general pathway to access wide range β-arylated alcohols, including tetrahydronaphthalen-2-ols benzopyran-3-ols, high excellent chemo- regioselectivity.