Alternarin A, a Drimane Meroterpenoid, Suppresses Neuronal Excitability from the Coral-Associated Fungi Alternaria sp. ZH-15

• DOI: 10.1021/acs.orglett.0c00746
• Publication Date: 2020-04-02T13:19:13Z
• Authors: Hong-Liang Wang; Ran Li; Jiao Li; Jing He; Zheng-Yu Cao; Tibor Kurtán; Attila Mándi; Gui-Liang Zheng; Wen Zhang
• Keywords: QD01 Analytical chemistry / analitikai kémia; Polycyclic Sesquiterpenes; QD04 Organic chemistry / szerves kémia; Molecular Conformation; Alternaria; Animals; Calcium; Agaricales; 01 natural sciences; Density Functional Theory; 0104 chemical sciences

Alternarin A (1), a rearranged drimane meroterpenoid characterized by a thioglycerate moiety, was isolated together with two known analogues from the coral-associated fungi Alternaria sp. ZH-15. Its structure was determined based on spectroscopic analysis, modified Mosher's method, and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, compound 1 effectively inhibited the activity of spontaneous synchronous Ca2+ oscillations and 4-aminopyridine induced epileptic discharges in the low micromolar concentration range.