Palladium-Catalyzed Three-Component Coupling of Ynamides

• DOI: 10.1021/acs.orglett.0c01426
• Publication Date: 2020-06-27T07:43:50Z
• Authors: Hideaki Wakamatsu; Ayano Takahashi; Ayaka Ishii; Youhei Kikuchi; Madoka Sasaki; Yukako Saito; Yoshihiro Natori; Yuichi Yoshimura
• Keywords: 01 natural sciences; 0104 chemical sciences

A palladium-catalyzed regioselective three-component coupling of ynamides was developed. The reaction proceeded smoothly to furnish the desired products when carried out at 70 °C in acetonitrile/water with potassium carbonate in the presence of 2.5 mol % Pd2(dba)3·CHCl3 without a ligand. Various iodides and boronic acids were used in this reaction, and a carbon-carbon bond was formed with satisfactory regioselectivity from the ynamides.