Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides

• DOI: 10.1021/acs.orglett.0c01869
• Publication Date: 2020-06-30T13:32:38Z
• Authors: Zhaohui Li; Long Liu; Kaiqiang Xu; Tianzeng Huang; Xinyi Li; Bin Song; Tieqiao Chen
• Keywords: 01 natural sciences; 0104 chemical sciences

A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids was achieved through C-N cleavage. This reaction showed a wide substrate scope. Both aromatic and aliphatic served well as the acylating reagents coupled with to produce corresponding amides in good excellent yields. With strategy, bioactive were also efficiently modified, highlighting synthetic value process organic synthesis.