Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides

• DOI: 10.1021/acs.orglett.0c01869
• Publication Date: 2020-06-30T13:32:38Z
• Authors: Zhaohui Li; Long Liu; Kaiqiang Xu; Tianzeng Huang; Xinyi Li; Bin Song; Tieqiao Chen
• Keywords: 01 natural sciences; 0104 chemical sciences

A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids was achieved through C-N cleavage. This reaction showed a wide substrate scope. Both aromatic and aliphatic acids served well as the acylating reagents and coupled with tertiary amines to produce the corresponding amides in good to excellent yields. With the strategy, bioactive carboxylic acids were also efficiently modified, highlighting the synthetic value of the process in organic synthesis.