Phosphine-Catalyzed Stereoselective Tandem Annulation Reaction for the Synthesis of Chromeno[4,3-b]pyrroles

• DOI: 10.1021/acs.orglett.0c02558
• Publication Date: 2020-08-20T16:34:50Z
• Authors: Zonghao Dai; Jin Zhu; Wenbo Su; Wuxian Zeng; Ziqi Liu; Ming Chen; Qingfa Zhou
• Keywords: Annulation; Tandem; Pyrrole; Reaction conditions; Cascade reaction

A phosphine-catalyzed tandem cyclization reaction has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives, which contain three consecutive asymmetric centers. The good yield, excellent stereoselectivity, and Z/E selectivity. new method is simple, requires only mild conditions, shows tolerance for various functional groups. Similarly, this can be catalyzed by chiral phosphine catalyst achieve synthesis.