Palladium-Catalyzed Decarbonylative Sonogashira Coupling of Terminal Alkynes with Carboxylic Acids

• DOI: 10.1021/acs.orglett.1c00768
• Publication Date: 2021-04-22T00:27:54Z
• Authors: Xinyi Li; Long Liu; Tianzeng Huang; Zhi Tang; Chunya Li; Wenhui Li; Tao Zhang; Zhaohui Li; Tieqiao Chen
• Keywords: Sonogashira coupling; Alkyne

A direct decarbonylative Sonogashira coupling of terminal alkynes with carboxylic acids was achieved through palladium catalysis. This reaction did not use overstoichiometric oxidants, thus overcoming the homocoupling issue alkynes. Under conditions, a wide range including those bioactive ones could couple readily various alkynes, providing relative general method for preparing internal