Rapid Access to N-Protected Sulfonimidoyl Fluorides: Divergent Synthesis of Sulfonamides and Sulfonimidamides

• DOI: 10.1021/acs.orglett.1c01118
• Publication Date: 2021-05-10T11:49:29Z
• Authors: Yongan Liu; Qijun Pan; Xiaojun Hu; Yong Guo; Qing-Yun Chen; Chao Liu
• Keywords: Primary (astronomy); Sulfonamide

Herein we report a practical and efficient copper-catalyzed approach for the conversion of various arenediazonium salts to corresponding N-protected sulfonimidoyl fluorides. This operationally simple protocol tolerates wide range functional groups can be applied late-stage modification complex bioactive molecules. Furthermore, pharmaceutically important primary sulfonamides sulfonimidamides derived from these valuable fluoride units were prepared in minimal synthetic steps.