Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl Bromides

• DOI: 10.1021/acs.orglett.1c01698
• Publication Date: 2021-07-08T15:44:01Z
• Authors: Juan Du; Xing Wang; Hongling Wang; Jinhu Wei; Xuan Huang; Jun Song; Junmin Zhang
• Keywords: Oxindole

A mild visible-light-induced Pd-catalyzed intermolecular radical cascade reaction of N-arylacrylamides with unactivated alkyl bromides is disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid Pd-radical species are involved as the key intermediates. Sophisticated bioactive oxindole derivatives bearing various substituents substitution patterns can be efficiently afforded through approach.