Bipyridine-Type Bidentate Auxiliary-Enabled Copper-Mediated C–H/C–H Biaryl Coupling of Phenols and 1,3-Azoles

• DOI: 10.1021/acs.orglett.1c01735
• Publication Date: 2021-07-02T15:17:34Z
• Authors: Rikuo Kajiwara; Shibo Xu; Koji Hirano; Masahiro Miura
• Keywords: Azole; Bipyridine

A copper-mediated dehydrogenative C–H/C–H biaryl coupling of phenols and 1,3-azoles has been developed. The key to its success is the introduction a bipyridine-type bidentate auxiliary, 4,4′-di(tert-butyl)-2,2′-bipyridine, on phenol oxygen, which readily prepared easily attachable, detachable, recyclable. reaction proceeds smoothly in presence copper salt alone form corresponding phenol-azole heterobiaryls, are prevalent motifs functional molecules such as excited-state intramolecular proton transfer materials.