Alkenylation and Arylation of Peptides via Ni-Catalyzed Reductive Coupling of α-C-Tosyl Peptides with Csp2 Triflates/Halides

• DOI: 10.1021/acs.orglett.1c02601
• Publication Date: 2021-09-20T11:14:26Z
• Authors: Xianghua Tao; Guobin Ma; Yanhong Song; Yunrong Chen; Qun Qian; Deli Sun; Hegui Gong
• Keywords: Tripeptide; Tosyl; Reductive elimination

A Ni-catalyzed reductive cross-coupling between α-C-tosyl peptides and Csp2 triflates/halides has been developed. This protocol enables the formation of various unnatural di- tripeptides containing vinyl aryl side chains, it expands applications in late-stage diversification peptides.