Electrochemical Radical Selenylation of Alkenes and Arenes via Se–Se Bond Activation

• DOI: 10.1021/acs.orglett.1c02661
• Publication Date: 2021-09-28T16:00:31Z
• Authors: Li Sun; Liwei Wang; Hesham Alhumade; Hong Yi; Hu Cai; Aiwen Lei
• Keywords: Diselenide

A novel electrochemical radical selenylation of alkenes and activated arenes without external oxidants is reported. The diselenide was fully transformed into Se-centered radicals through Se-Se bond activation. Three-component carbonselenation successfully realized using styrenes to trap the RSe radical. Besides, direct coupling with further developed. Using this atom-economic protocol, diversity unsymmetric aryl-aryl, aryl-alkyl, alkyl-alkyl selenoethers obtained regioselectively, which has potential application in biological chemistry.