Total Synthesis of Paclitaxel

• DOI: 10.1021/acs.orglett.1c03851
• Publication Date: 2021-12-14T14:12:11Z
• Authors: Shota Iiyama; Keisuke Fukaya; Yu Yamaguchi; Ami Watanabe; Hiroaki Yamamoto; Shota Mochizuki; Ryosuke Saio; Takashi Noguchi; Takeshi Oishi; Takaaki Sato; Noritaka Chida
• Keywords: Oxetane; Silyl enol ether; Enol ether

The total synthesis of paclitaxel (Taxol) is described. Double Rubottom oxidation the bis(silyl enol ether) derived from a tricarbocyclic diketone effectively installed bridgehead olefin and C-5/C-13 hydroxy groups in one-step operation. novel Ag-promoted oxetane formation smoothly constructed tetracyclic framework paclitaxel.