Photoinduced Three-Component Difluoroamidosulfonylation/Bicyclization: A Route to Dihydrobenzofuran Derivatives

• DOI: 10.1021/acs.orglett.2c00761
• Publication Date: 2022-03-29T15:47:06Z
• Authors: Qitao Shen; Xiangyun Zheng; Lianghao Li; Tianshuo Zhong; Chuanliu Yin; Chuanming Yu
• Keywords: Component (thermodynamics); Hydrogen atom; Functional group

A visible-light-induced photocatalyst-free three-component radical cascade bicyclization has been achieved to obtain diverse difluoroamidosulfonylated dihydrobenzofurans in moderate good yields. This protocol avoids potential toxicity and the tedious removal procedure for photocatalysts also features mild reaction conditions a functional group tolerance. Moreover, mechanistic investigations reveal formation of charge-transfer complex involvement an intramolecular 1,5-hydrogen atom transfer process this transformation.