Light-Mediated Defluorosilylation of α-Trifluoromethyl Arylalkenes through Hydrogen Atom Transfer

• DOI: 10.1021/acs.orglett.2c01448
• Publication Date: 2022-05-25T10:47:09Z
• Authors: Fuyang Yue; Jianhua Liu; Henan Ma; Yuxiu Liu; Jianyang Dong; Qingmin Wang
• Keywords: Silanes; Hydrogen atom; Surface Modification; Photoredox catalysis

Herein, we report a direct, light-mediated defluorosilylation protocol for converting α-trifluoromethyl arylalkenes and alkyl silanes into γ,γ-difluoroallylic compounds via combination of photoredox catalysis hydrogen atom transfer. The clean, convenient can be scaled to the gram level, its mild conditions make it very suitable late-stage functionalization complex natural products drugs.