Dearomatization [4+2] Cycloaddition of Nonactivated Benzene Derivatives

• DOI: 10.1021/acs.orglett.2c01630
• Publication Date: 2022-06-10T17:02:20Z
• Authors: Junjian Wang; Haotian Luo; Xinghua Wang; Donghui Wei; Rongqiang Tian; Zheng Duan
• Keywords: Benzene derivatives; Reactivity

Dearomatization reactions have recently emerged as a powerful tool for the rapid buildup of molecular complexity. Here, an unparalleled thermal dearomatization [4+2] cycloaddition reaction between benzene derivatives and 2H-phosphindole tungsten complex was reported. The unique reactivity in situ-generated toward revealed by density functional theory calculations. We thus provide new insights into nonactivated arenes pave way manipulation further applications.